SERIES I 

Study Design

Principal Investigator: Dr. Sameer Dani    Study Title: A study with the Supralimus® Sirolimus Eluting Stent in the treatment of patients with real world coronary artery   lesions.    Study Design: Real world, Non randomized, multi centric study. One hundred patients were enrolled.    Study Objective: The primary objective of this study is to assess the safety and efficacy of the Supralimus® Sirolimus Eluting Stent in   real world coronary artery lesions    Status: Ongoing *Published in EuroIntervention May 2008

Baseline Patient Characteristics (n=100) Variable (%)   Diabetes Mellitus 29%   Hypertension 57%   Hyperlipidaemia 38%   Smoker 22%   Previous Myocardial Infarction 56%   Heart failure 7%   Previous PCI 6%     Lesion Characteristics (n=126) Variable     Chronic occlusion 17 (12%)   In stent restenosis 1 (1%)   Ostial lesion 8 (5%)   Bifurcation 5 (3%)

Major adverse clinical events (n=100) Variables 1 Month 6 Months 9 Months 24 Months 30 Months Death (%) 0 1 2 3 3 Non-fatal Myocardial Infarction (%) 0 0 0 0 0 Death or nonfatal MI (%) 0 1 2 3 3 TVR (%) 0 2 4 4 4 Death or nonfatal MI or TVR (%) 0 3 6 7 7 Freedom from MACE (%) 100 97 94 93 93

Quantitative coronary angiographic analysis (n=59)   Baseline Post-procedure 6 months Reference vessel diameter, mm                 In stent 2.66 ± 0.62 2.86 ± 0.45 2.85 ± 0.46           In segment   2.80 ± 0.47 2.77 ± 0.48 Minimum lumen diameter, mm                 In stent  0.73 ± 0.61 2.53 ± 0.43 2.44 ± 0.48           In segment   2.14 ± 0.49 2.11 ± 0.51 Late loss, mm                 In stent     0.09 ± 0.28           In segment     0.02 ± 0.37 Diameter stenosis, %                 In stent  72.4 ± 21.7 11.5 ± 6.6 14.2 ± 9.9           In segment   24.0 ± 9.3 23.9 ± 12.7 Binary angiographic restenosis, n (%)                 In stent     0 (0)           In segment     1 (1.7) Reference vessel area, mm2                 In stent  5.85 ± 2.78 7.05 ± 3.41 6.84 ± 2.83           In segment   6.41 ± 2.54 6.51 ± 2.42 Minimum lumen area, mm2                 In stent 0.91 ± 1.08 6.24 ± 2.99 5.63 ± 2.67           In segment    4.28 ± 2.45 4.30 ± 2.24 Area stenosis, %                 In stent   84.4 ± 15.9 10.1 ± 21.8 18.0 ± 19.8           In segment   34.0 ± 20.5 34.8 ± 20.7